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  • 10 Biggest Celebrity Guest Stars To Appear On Grey’s Anatomy – Screen Rant

 April 10

by Carolina

Content Warning: the following article contains discussions of medical themes.

The show Grey’s Anatomy remains a television sensation, sixteen years after it first premiered in 2005. Throughout the show’s many seasons, numerous guest stars walked down the hallways of the former Seattle Grey Hospital, now Grey Sloan Memorial.

Some of them won critical acclaim for their performances, and one even won the coveted Primetime Emmy Award for Guest Acting in a Drama Series. But with so many guest performers in the long-running show, only a few truly stand out.

10 Loretta Devine

Loretta Devine Greys Anatomy

Television veteran Loretta Devine played the role of Adele Webber, Richard Webber’s wife, for 22 episodes, over the course of seven seasons. For her performance in the show’s sixth season, she won the Primetime Emmy Award for Outstanding Guest Actress in a Drama Series. She received a second nomination the following year.

Devine first gained prominence as Lorell in the original Broadway production of Dreamgirls. She went on to appear in numerous television shows over the years, like A Different WorldThe PJs, and Boston Public.

9 Demi Lovato

Back in 2010, when she was still a part of the Disney Channel machine, Lovato appeared in the episode titled “Shiny Happy People.” She played Hayley May, a young woman recently diagnosed with schizophrenia. Lovato’s performance was generally well-received, although most of the praise went for the episode’s other major guest star, television icon Marion Ross.

Lovato went on to have a successful musical career, with only sporadic appearances in both film and television. For her performance in the episode, she won a People’s Choice Award.

8 Mandy Moore

Mandy Moore rose to prominence in the late 90s thanks to her single “Candy.” She later starred in a series of successful teen movies like The Princess DiariesA Walk to Remember, and Saved!. Starting in 2016, Moore found critical acclaim thanks to her role as Rebecca Pearson in This is Us, for which she received nominations for the Primetime Emmy Award and the Golden Globe.

Moore played Mary Portman in 4 episodes of Grey’s Anatomy‘s sixth and seventh seasons. She memorably gets trapped with Bailey during a hospital shooting and later returns to get surgery, but doesn’t find a happy ending.

7 Christina Ricci

One of the most famous child stars of the early 90s. Christina Ricci went on to successfully transition into adult roles. She starred in the dark comedy The Opposite of Sex – for which she received a Golden Globe nomination in 1999 – and had leading roles in films like Sleepy HollowMonster, and Speed Racer.

Ricci is one of Grey’s most memorable guest stars. She played Hannah, a young paramedic with her hand stuck inside a man’s chest cavity, holding a piece of unexploded ammunition. Ricci received critical acclaim for her performance, as well as an Emmy nomination for Outstanding Guest Actress. The episode itself, “It’s the End of the World,” often ranks as one of the series’ best.

6 Leslie Odom Jr.

Long before Leslie Odom Jr. rose to prominence, and won a Tony Award for Hamilton, he guest-starred in Grey’s Anatomy‘s fifth season. He played P.J. Walling, a man who donates his kidney in exchange for $10,000.

Odom Jr.’s career took off after his starring role in Hamilton. This year, he received a plethora of nominations. including for the Golden Globes, SAG, BAFTA, and Academy Awards thanks to his performance as Sam Cooke in Regina King’s directorial debut, One Night in Miami.

5 Sarah Paulson

Long before she became a staple of the Ryan Murphy-verse, Sarah Paulson played the role of a young Ellis Grey in the tenth season episode “The Time Warp.” The plot features several flashbacks, one of which centers on Ellis and Richard treating a patient diagnosed with a virus later called HIV/AIDS.

Paulson’s name already was familiar to tv viewers by the time she guest-starred in Grey’s, but her journey to critical acclaim had yet to begin. The following year she received an Emmy nomination for Game Change. the first of seven. She finally won the statuette in 2016 for her role as Marcia Clark in The People v. O.J. Simpson.

4 Alyssa Milano & Holly Marie Combs

Richard tells Haylee and Heidi Peterson to stop fighting

Piper and Phoebe Halliwell returned to television during Grey’s 16th season. The episode – aptly titled “Reunited” – features Holly Marie Combs and Alyssa Milano as sisters trying to decide if they should or should not take their third sister off life support.

The two actresses starred as two-thirds of the Charmed ones in The WB’s Charmed. Before that, Milano was best-known for her roles in Who’s the Boss and Melrose Place, while Combs made a name for herself thanks to Picket Fences.

3 Tessa Thompson

Tessa Thompson had her big break in 2015 when she played the role of Blanca Taylor in Creed. Soon after, she received the coveted and pivotal role of Valkyrie in Thor: Ragnarok, thus becoming part of the Marvel Cinematic Universe.

Nearly ten years before that, though, Thompson played the role of Camille Travis, Richard Webber’s niece. Diagnosed with ovarian cancer at fourteen, she’s unable to attend her prom and the staff at Seattle Grace throws one for her at the facilities.

2 Kyle Chandler

Dylan Young briefs the Seattle Grace staff about the bomb situation

Shortly before Chandler received the role of Coach Taylor in Friday Night Lights, he appeared in two Grey’s episodes, “It’s the End of the World” and “As We Know It.” He played Dylan Young, a bomb squad leader who meets an untimely and shocking ending.

For his role in Grey’s, Chandler received his first Emmy nomination. He’d go on to win the statuette for Friday Night Light‘s final season. He keeps steadily working in both film and television, and the most recent entry in his filmography is the blockbuster Godzilla vs. Kong.

1 Millie Bobby Brown

Chandler’s Godzilla co-star Millie Bobby Brown received instant critical acclaim thanks to her role in Stranger Things. For her performance as Eleven, Brown received two consecutive Emmy nominations, although she failed to win any of them.

Before her breakthrough in the Netflix hit, Brown played Ruby in season eleven of Grey’s. After a powerful earthquake hurts her mother, Ruby needs to care for her, receiving indications from Seattle Grace’s medical staff. The two eventually get to the hospital, where the mother survives her surgery.

NEXT: 10 Saddest Grey’s Anatomy Episodes, Ranked By IMDb



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About The Author


David Caballero
(243 Articles Published)

David is a twenty-eight-year-old Mexican writer and reader. Having studied Marketng in school, he spent three years working a nine-to-five desk job before deciding to pursue a writing career. He now works as a List Writer in ScreenRant and does some more freelancing job, talking about the entertainment business he so loves. Currently, he’s also writing his second novel while actively working to get his first one published.

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Original posted at screenrant.com

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